If you are looking to collect information from others or allow them to
interact with information from other sources then InfoPath is the way to go
and will be a better environment for doing so. However if you are doing
Excel core competencies, running calculations on large data sets than
InfoPath may not be the best.
Making the jump between the two, to create InfoPath forms, is not that
difficult but most of your Excel skills will not be that relevant.
Clay Fox / Microsoft InfoPath MVP
www.InfoPathDev.com / The InfoPath Authority / Downloads, Samples, How-To,